St. Thomas College (Autonomous), Thrissur, boasts a distinguished faculty across various disciplines, contributing to its reputation for academic excellence. Here's an overview of some key faculty members:​

  Administrative Leadership

• Fr. Dr. K. A. Martin – Principal and Associate Professor in the Department of English
• Dr. Joyce Jose – Dean of Research  

  Faculty Members by Department

English

• Dr. Anto Thomas C. – Professor and Dean of International Affairs, Research Guide
• Dr. Anu Paul – Assistant Professor & Head of the Department, Research Guide
• Dr. Viju M. J. – Associate Professor, Research Guide
• Dr. Syam Sudhakar – Assistant Professor, Research Guide ​

Commerce

• Dr. Biju John M. – Professor & Dean of Arts and Humanities, Research Guide
• Dr. Daisland Thattil – Assistant Professor & Head of the Department
• Dr. Divya George – Assistant Professor & IQAC Coordinator
• Dr. Vipin Benny – Assistant Professor & Research Guide ​

Computer Science & Data Science

• Dr. Jiju A. Mathew – Assistant Professor
• Mr. Rejin Varghese – Assistant Professor & Head of the Department
• Mrs. Sonia V. V. – Assistant Professor
• Mrs. Sreelekha K. – Assistant Professor ​

Physics

• Dr. Joe Kizhakooden – Assistant Professor and Head of the Department ​

Chemistry

• Dr. Paulson Mathew – Professor & Head of the Department ​

Mathematics

• Dr. Saju M. I. – Assistant Professor